Talk Recordings
How do cells control their size?
Recording of Dr. Evgeny Zatulovsiy's talk at the London Cell Cycle Club meeting (July, 2020).
This talk describes how cell growth dilutes a key cell cycle inhibitor RB to trigger a cell-size-dependent cell division. This provides a long-sought molecular mechanism for maintaining the cell size homeostasis in animal tissues.
More details can be found in the following publications:
E. Zatulovskiy, S. Zhang, D.F. Berenson, B.R. Topacio, J.M. Skotheim. Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division. – 2020 – Science – 369(6502): 466-471.
S. Zhang, E. Zatulovskiy, J. Arand, J. Sage and J.M. Skotheim. The cell cycle inhibitor Rb is diluted in G1 and contributes to controlling cell size in the mouse liver. – 2022 – Front Cell Dev Biol. 10: 965595.
E. Zatulovskiy, J.M. Skotheim. On the molecular mechanisms regulating animal cell size homeostasis. – 2020 – Trends Genet. – 36(5): 360-372 (Review).
Why do cells control their size?
Recording of Dr. Evgeny Zatulovsiy's talk for the ASCB|EMBO CellBio-2022 Meeting.
This talk discusses how cell size and cell growth rate (i.e. biosynthesis rate) affect gene expression, cell physiology and ageing in human cells.
This work is a result of a fruitful collaboration with Michael Lanz and Josh Elias (CZ Biohub), as well as Shuyuan Zhang, Matthew Swaffer and other members of the Skotheim lab (Stanford). See a quick summary on the Chan Zuckerberg Biohub website.
More details are described in the following publications:
M.C. Lanz*, E. Zatulovskiy*, M.P. Swaffer, L. Zhang, I. Ilerten, S. Zhang, D.S. You, G. Marinov, P. McAlpine, J.E. Elias, J.M. Skotheim. Increasing cell size remodels the proteome and promotes senescence. – 2022 – Mol Cell. 82(17): 3255-3269.e8.
E. Zatulovskiy*, M.C. Lanz*, S. Zhang, F. McCarthy, J.E. Elias, J.M. Skotheim. Delineation of proteome changes driven by cell size and growth rate. – 2022 – Front Cell Dev Biol. 10: 980721.